canescens es una sinonimia del nombre aceptado como Ajuga integrifolia. Significant reduction of fasting BGL was noticed following the repeated daily doses of AIRE after the 7th day and 14th day of treatment compared to both diabetic control and baseline. [family LABIATAE] Herbarium. Compared to groups treated by both repeated daily doses of crude extract and aqueous fraction of AIRE, the bodyweight of the diabetic control group was reduced significantly after two weeks of treatment. For fractionation, 100 g of methanol crude extract was suspended in a separatory funnel with 400 ml of distilled water. It causes pancreatic β-cell destruction via DNA alkylation and strand breakage, thereby causing diabetes mellitus [36, 37]. Bodyweight of mice received 200 mg/kg and 400 mg/kg aqueous fraction but not 100 mg/kg was considerably improved at 7th day and 14th day, with percentage increment of 4.95% and 6.32%, respectively, compared to the baseline. Oral glucose tolerance test of crude root extract of. The dried roots of the plant were pulverized into coarse powder by an appropriate electrical miller. The coarse powdered roots of the plant were macerated in 80% methanol in a ratio of 750 g of sample material: 7.5 liters of solvent (w/v) separately. Significant difference in baseline fasting BGL was not observed throughout all groups. 425 guideline, the acute oral toxicity test was performed [19]. SPSS version 21 software was used to do statistical analysis. A single dose of AIRE ranging from 100 mg/kg to 400 mg/kg and GLC 5 mg/kg were given to mice in the normoglycemic model. It was evident that the BGL of mice reached its climax after 30 minutes of administration, and then, it decreased mildly at 60 minutes and reduced nearly to the normal level after 2 hours of glucose administration. Ajuga parviflora is a type of bugleweed that is found in places like Afghanistan, India, Pakistan, and the disputed Kashmir region. Both taxonomists and users of taxonomies should benefit from this. ex D.Don is pharmacologically important plant, commonly known as Kori Booti. It is expected that cost will be USD 825 billion by 2030 and USD 845 billion by 2045 [5]. Molalegn Alene, Mohammedbrhan Abdelwuhab, Assefa Belay, Taklo Simeneh Yazie, "Evaluation of Antidiabetic Activity of Ajuga integrifolia (Lamiaceae) Root Extract and Solvent Fractions in Mice", Evidence-Based Complementary and Alternative Medicine, vol. The doses of 100 mg/kg, 200 mg/kg, and 400 mg/kg AIRE reduced fasting BGL with a magnitude of 16.10%, 21.6%, and 26.4% after 7th day of treatment and 18.5%, 24.6%, and 28.8% after 14th day of treatment compared to the respective baseline BGL. Ham. In the present study, adequate data were generated that uphold the claimed antihyperglycemic activity of the medicinal plant Ajuga integrifolia in the community. When within group analysis was performed, the difference in reduction of fasting BGL was not significant at all time points compared to both the diabetic control and the respective baseline values of all fractions. [2] Son naturales de Europa, Asia y África. Blood samples were taken from the tail vein of each mouse by cutting the tip of the tail aseptically in all mice models. Ajuga species can grow in either full sunlight or in the shade. Weight loss of the mice is often associated to STZ and hyperglycaemic complication [22]. Overnight fasted diabetic mice were arranged into 5 groups (each group comprised of 6 mice) at random. This way modulation of blood glucose is consistent with the reports by Belayneh and Birru [23] and Anitha et al. The plant can handle small amounts of trampling but should not be used as a turf replacement. A standard drug in all cases was glibenclamide (5 mg/kg), and the blood glucose level was measured by using a glucose meter. Thus, the present study was performed to determine the antidiabetic activity of the root extract and solvent fraction of Ajuga integrifolia in mice. Antihyperglycemic mechanism(s) of action of Ajuga integrifolia might be attributed to potentiating of the effect of insulin either by escalating the release of insulin from β-cells of pancreas, increasing the utilization of glucose by peripheral tissue, reducing hepatic gluconeogenesis, inhibiting metabolic degradations of carbohydrates, or by preventing oxidative stress [43]. Ajuga integrifolia là một loài thá»±c vật có hoa trong họ Hoa môi. Significant difference in baseline BGL was not found throughout groups prior to the start of DW, AIRE, and GLC administration (Table 2). Then, the n-hexane layer so formed was poured into a beaker and labeled as “n-hexane fraction.” The aqueous remainder was again mixed with same quantity of chloroform and shaken similarly, and the chloroform layer obtained was decanted to a second beaker and labeled as “chloroform fraction” likewise. Para su información, una sinonimia no es más que otro nombre científico para un mismo taxón. Zajímavosti ze světa rostlin. Compared to baseline, fasting BGL was reduced by GLC, with percentage reduction of 60.8% and 65.2% after 7th day and 14th day of treatment, respectively. Entry From. Moreover, in repeated daily dose experiment, the GLC-treated group showed a significant reduction in BGL at 7th day and 14th day compared to groups that received various doses of aqueous fraction and crude extract of Ajuga integrifolia root. Rezervace, chráněná území a jiné významné botanické lokality. Management of DM includes diet modification, exercise, weight loss, oral hypoglycemic agents, and insulin; however, none of them can treat the underlying cause of the disease nor can they cure the illness consequently [2, 3, 6]. GLC showed the antihyperglycemic effect in diabetic mice, and literature acknowledged that GLC exerts its effect by selectively blocking the ATP sensitive K+ channels (KATP) in the β-cells of the pancreas. Nevertheless, the present study recommends more in-depth molecular studies to determine the precise mechanism of Ajuga integrifolia to lower blood glucose. Hydromethanolic crude extract and its aqueous fraction of Ajuga integrifolia root showed a considerable blood glucose lowering activity at all doses. First, STZ was dissolved in 0.1 M cold citrate buffer (pH = 4.5). [1] Comprende 188 especies descritas y de estas, solo 70 aceptadas. The dirt and particulate matter was removed from the root of Ajuga integrifolia by washing rigorously with distilled water. Antioxidants are known to prevent oxidative stress, thereby treating DM and its complications [14–16]. This member of the mint family spreads fast and can become invasive. Finally, 12 g hexane and 17 g of chloroform fractions and 2 g of oleaginous jelly matter were obtained with the remaining 69 g being aqueous fraction. Worldwide, more than 1000 plants have been known as efficacious in the treatment of DM. The botanical identification and authentication of the plant material was performed by a botanist, and voucher specimens (MA001/2019) were deposited in Herbarium of Biology Department, Faculty of Natural and Computational Science, University of Gondar. The extract was more appreciably soluble in water than in organic solvent producing yields of hexane (12%), chloroform (17%), aqueous (69%), and remaining olegenous residue (2%). There was no significant change in bodyweight of the normal control compared to its baseline weights. Ajuga integrifolia var. Our Ajuga extract is made from Ajuga turkestanica standardized to 2% total ecdysteroids. Significant reduction in BGL was observed in the GLC received group at 7th day and 14th day compared to the diabetic control, and also, BGL was reduced dramatically compared to 100 mg/kg, 200 mg/kg, and 400 mg/kg aqueous fraction at the 7th day and 14th day. Chú thích Liên kết ngoài. In East Africa, plants of the genus Ajuga have been used as a remedy for fever, toothache, severe stomachache, dysentery, high blood pressure, malaria, edema, pneumonia and liver problems [4, 10]. Learn more about Ajuga Nipponensis uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain Ajuga Nipponensis It is usually used to detect persons at risk of prediabetes and diabetes [39, 40]. Overnight fasted mice were divided into 5 groups (6 mice in each group) at random. Mice were randomly divided into five groups (6 mice per group) in the normoglycemic, oral glucose loaded, and one dose treated diabetic mice models. Ajuga integrifolia is an herb belonging to Lamiaceae family under genus Ajuga and is locally known as “Tut Astel” and “Akorarach” in Amharic and “Harmegusa” in Oromifa in various parts of Ethiopia [9–11]. The fasting BGL of the diabetic control was increased on the 7th day and 14th day of treatment compared to the baseline value. The increased fasting BGL at 30 minutes can be explained that the glucose oral load was absorbed and reached systemic circulation by this time. Long-term damage and failure of the eyes, kidneys, nerves, heart, and blood vessels were evident in chronic hyperglycemia [2]. Overnight fasted STZ-induced diabetic mice and normal mice were grouped into 6 groups (5 groups of mice having diabetes and 1 group of normal mice, 6 mice in each group) at random. Ajuga. Development of DM involves different pathogenic processes, and these range from autoimmune destruction of the pancreatic β-cells that result in absolute insulin deficiency to abnormalities that result in insulin resistance. Entry for AJUGA bracteosa Wall. A frost hardy, low growing plant that has a spreading habit - not unlike the strawberry - by sending out runners to make leafy mat out of which grow spikes of blue flowers in spring. The AIRE 200 mg/kg and 400 mg/kg reduced fasting BGL significantly at the 7th day and 14th day compared to the baseline value. It has dark green oval leaves and makes a good, colourful groundcover One-way ANOVA followed by Tukey’s post hoc multiple comparison test was used to compare means of all parameters among groups and within groups. Traditional healers and the community have used the roots of Ajuga integrifolia for the treatment of diabetes mellitus. The protocol of the study was approved by the Research and Ethics Committee of Department of Pharmacology, School of pharmacy, University of Gondar, prior to commencing the study with reference number (school of pharmacy 12-112-2012). It reduced fasting BGL considerably at these time points compared to the diabetic control as well. Among the three single different doses of aqueous fractions, AQA 400 mg/kg showed highest blood glucose lowering activity. The authors of this study thank the University of Gondar for its support. It was screened phytochemically and reported that terpenoides, glycosides, tannins, flavonoids, alkaloids, steroids, phenols, and saponins were most commonly isolated biologically active principles responsible for its medicinal properties [13]. Mice were screened for diabetes after 3 days of STZ injection, and fasting BGL > 200 mg/dl was included in the study as diabetic mice [25, 26]. mô tả khoa học đầu tiên năm 1825. pero también dos especies se encuentran en Australia.Tienen hojas opuestas de 5-50 cm. The loss of bodyweight in STZ-induced diabetic mice was significantly improved by GLC () at the 14th day of treatment compared to the diabetic control. When different doses of the hydromethanolic root crude extract, baseline value, and negative control group were compared to GLC, GLC reduced the fasting BGL significantly at 2nd hr, 4th hr, and 6th hr. Alternatively, a slow-release low-nitrogen fertilizer can be used. Lamiaceae (inc. Verbenaceae) Fortnight: Lamiaceae-Ajuga bracteosa from Batote J & K-GSMAY02/05 : 1 post by 1 author. In Ethiopia, Ajuga integrifolia occurs in different regions including Amhara, Southern Nation, Nationalities and People (SNNP), Tigray, and Oromia [12]. Ajuga integrifolia Buch. The data were presented as mean ± standard error of the mean (M ± SEM). A mouse receiving 400 mg/kg crude root extract showed a statistically significant reduction in BGL at 2nd hr compared to 100 mg/kg and 200 mg/kg treated groups. canescens es una sinonimia del nombre aceptado como Ajuga integrifolia. Por favor haga click en el siguiente enlace para proceder de forma manual Ajuga integrifolia. In comparison to the diabetic control, GLC significantly improved the bodyweight loss of STZ-induced diabetic mice at 7th day and 14th day of treatment (Table 5). As far as the major finding of this investigation is concerned, Ajuga integrifolia root extract has antihyperglycemic activities. Acclimatization of the mice to the laboratory conditions was performed for 1 week prior to the start of the experiment. Reference Sources. Sign up here as a reviewer to help fast-track new submissions. No toxicity incidences have been reported related to Ajuga integrifolia in particular and the genus Ajuga in general so far [24, 33–35]. After overnight fasting, mice were divided into eleven groups (n = 6) at random: group 1 serving as the diabetic control group receiving 10 ml/kg DW, group 2 receiving aqueous fraction 100 mg/kg of AIRE, group 3 receiving aqueous fraction 200 mg/kg of AIRE, group 4 receiving aqueous fraction 400 mg/kg of AIRE, group 5 receiving hexane fraction 100 mg/kg of AIRE, group 6 receiving hexane fraction 200 mg/kg of AIRE, group 7 receiving hexane fraction 400 mg/kg of AIRE, group 8 receiving chloroform fraction 100 mg/kg of AIRE, group 9 receiving chloroform fraction 200 mg/kg of AIRE, group 10 receiving chloroform fraction 400 mg/kg of AIRE, and group 11 receiving GLC 5 mg/kg, and BGL of every mouse was determined at 0 hr, 2 hr, 4 hr, 6 hr, and 8 hr of AIRE fractions administration. Therefore, the oral median lethal dose (LD50) of the AIRE can be considered to be more than 2000 mg/kg. Publicado en Lamiaceae, window.setTimeout(function() { window.location.href = "http://www.botanicayjardines.com/ajuga-integrifolia/redirigido-desde/sinonimia-ajuga-integrifolia-var-canescens/"; }, 10000); document.write('Usted será redirigido de forma automática a la ficha correcta en 10 segundos. At 120 minutes, all AIRE-treated groups showed blood glucose reduction to a level comparable to their respective baseline values. GLC was used as a standard drug on basis of previous reports on earlier literatures [23, 24]. Resource Type. Benefits of Bugleweed Image by Katja Schulz / CC BY-SA 2.0 With its scientific name ajuga bracteosa and ajuga integrifolia, this plant is also known as bracted bugleweed, blue bugle, bungle, and small-flowered bugleweed, in English. It is not scientifically validated for its antidiabetic activity previously. They should be spaced 15 to 30 cm apart in the spring or autumn. Tenen les fulles oposades de 5 - 50 centímetres de llargària i les flors presenten un color blavós cendra. However, AIRE 100 mg/kg, 200 mg/kg, and 400 mg/kg reduced fasting BGL approximately close to baseline and virtually similar to the GLC treated group at 120 minutes. The plant will thrive in both shady and sunny locations. The study was conducted based on the recommendations of the Guide for the Care and Use of Laboratory Animals [28]. When GLC-treated groups were compared with the different extract dose treated groups, there was a significant reduction in the GLC-treated group () compared to 200 mg/kg and 400 mg/kg AIRE, compared to 100 mg/kg AIRE at the 7th day and 14th day, and compared to diabetic control (Table 4). The elevation of blood glucose in this pattern and its reduction at these times is consistent with the one reported by Belayneh and Birru [23]. BGL was determined prior to the starting of treatment (at 0 hr) as baseline, and then, following treatment at 2 hr, 4 hr, 6 hr, and 8 hr. Diabetes mellitus was effectively induced by administering STZ solution (150 mg/kg) to all groups of mice. Overnight fasted STZ-induced diabetic mice were grouped into 6 groups (6 mice per groups) at random. Therefore, the objective of the present study was to determine the hypoglycemic and antidiabetic activity of Ajuga integrifolia. Ajuga es un género de plantas con flores, caducas y perennes de la familia Lamiaceae. Review articles are excluded from this waiver policy. All the authors approved the submitted version of the manuscript. They grow to 5–50 cm tall, with opposite leaves. Loài này được Buch.-Ham. F. Assefa, “Antidiabetic activity of ajuga remota benth (harmegusa) leaves in streptozotocin induced diabetic rats,” Addis Ababa University, Addis Ababa, Ethiopia, 2013, Thesis. A. Martínez, “Reactive species and diabetes: counteracting oxidative stress to improve health,”, R. P. Robertson, “Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes,”, D. L. Keshebo, A. P. Washe, and F. Alemu, “Determination of antimicrobial and antioxidant activities of extracts from selected medicinal plants,”, A. Pala, M. Jadona, Y. K. Katarea et al., “Ajuga bracteosa wall: a review on its ethnopharmacological and phytochemical studies,”, M. C. Deeds, J. M. Anderson, A. S. Armstrong et al., “Single dose streptozotocin-induced diabetes: considerations for study design in islet transplantation models,”, P. Vital, E. Larrieta, and M. Hiriart, “Sexual dimorphism in insulin sensitivity and susceptibility to develop diabetes in rats,”, B. L. Furman, “Streptozotocin-induced diabetic models in mice and rats,”, Y. M. Belayneh and E. M. Birru, “Antidiabetic activities of hydromethanolic leaf extract of calpurnia aurea (ait.) Then, each mouse’s BGL was determined at 1 hr, 2 hr, 4 hr, and 6 hr posttreatment [23, 24]. Group 1 (negative control) was treated with 10 ml/kg DW; the 9 experimental groups received solvent fraction of the root extract of the plant (groups 2, 3, and 4 received three different doses of aqueous fraction of the root extract of the plant; groups 5, 6, and 7 received three different doses of n-hexane fraction of the root extract of the plant; and groups 8, 9, and 10 received three different doses of chloroform fraction of the root extract of the plant). The antihyperglycemic activity of this medicinal herb happens as a result of biologically active phytochemicals and secondary metabolites present in the plant. Compared to repeated daily doses at 7th day and 14th day, single dose 200 mg/kg and 400 mg/kg AIRE showed lesser reduction of fasting BGL at 6th hr and 8th hr supporting that the repeated daily doses of AIRE have better antidiabetic activity than the single dose. Then, the remaining solvent free extract was kept alone in a desiccator till it was used for the study and the fractionation process in case the extract could contain hygroscopic element. The mice were stayed in light and dark cycle (12 hours of each cycle) which is a standard condition for laboratory animals and permitted open access to standard pellet diet and water ad libitum. In addition, the roots of Ajuga integrifolia have larger amounts of chromium which may be correlated to its use as treatment for DM [18]. Free radical mediated reactions are terminated by plants and drugs of plant origin that have abundant antioxidants, thereby preventing the body from oxidative damage and stress [30–32]. Working to the all cases, group 1 used as negative control was treated with 10 ml/kg distilled water (DW). Uptake of, S. Andrikopoulos, A. R. Blair, N. Deluca, B. C. Fam, and J. Proietto, “Evaluating the glucose tolerance test in mice,”, M. Anitha, G. Sakthidevi, S. Muthukumarasamy, and V. R. Mohan, “Effect of Cynoglossum zeylanicum (Vehl ex Hornem) Thunb. Para su información, una sinonimia no es más que otro nombre científico para un mismo taxón. Then, root of Ajuga integrifolia was dried under shade at room temperature (20–30°C) with most favorable ventilation. Flora of Tropical … Swiss albino male mice which were healthy weighed 20–30 g and aged 8–12 weeks were used in the study, and healthy female mice having similar weight and age to males were used for the acute oral toxicity study. The oral glucose tolerance test is a suitable model to measure and evaluate the insulin action and tissues sensitivity to insulin whose pancreatic release is stimulated by ingestion of glucose. Ajuga integrifolia Buch.-Ham. Therefore, you will want to be careful and strategic about where you plant it. Ajuga parviflora, the plant depicted at FOI website and the plant uploaded here is densely villous plant with much smaller leaves, scarcely exceeding 4 cm, much smaller flowers usually smaller than 8 mm in length.There are no specially coloured floral leaves, the floral clusters occurring in axils of normal leaves, corolla tube slightly longer than calyx, stamens or mostly included. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Then, blockage of KATP results in the influx of Ca2+ to cells which, in turn, cause depolarization in the cytosol with subsequent insulin secretion [39]. According to the results of the first mouse, another four female mice were recruited and fasted for 4 hours and then given a single dose of 2 g/kg and was observed rigorously in the same manner. Copyright © 2020 Molalegn Alene et al. BGL and bodyweight of the mice were determined prior to starting treatment on the 1st day (baseline), 7th day, and 14th day [27, 28]. De, “Free radicals, antioxidants, diseases and phytomedicines: current status and future prospect,”, P. K. Prabhakar and M. Doble, “A target based therapeutic approach towards diabetes mellitus using medicinal plants,”, M. C. Sabu and R. Kuttan, “Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property,”, K. Cocquyt, P. Cos, P. Herdewijn, L. Maes, P. E. Van den Steen, and G. Laekeman, “Ajuga remota Benth. Next, mice were given DW, root crude extract of the plant, and GLC according to grouping stated above. Ajuga remota in particular is traditionally used as a herbal remedy for fever and infections, and is prescribed for malaria by 66% of the Kenyan herbalists. The diabetic control and normal controls were given 10 ml/kg DW; three different doses of root extract were given to diabetic treatment groups, whereas the diabetic positive control group received 5 mg/kg GLC all dosed once daily for 14 days. Within groups’ analysis of data revealed that fasting BGL was reduced in groups that received crude extract compared to the respective baseline values at all time points. The nodes of the stolons are also very short, which creates very dense colonies ideal for preventing weeds from growing up through the plants. A large number of compounds have already been isolated from A. remota , including ergosterol-5,8-endoperoxide ( 6 ), ajugarin-I ( 1 ), 8- O -acetylharpagide ( 5 ) and several phytoecdysteroids. The fasting BGL of the normal control groups, however, did not exhibit remarkable change throughout the study period. According to between groups’ analysis, groups treated with repeated daily doses of aqueous fractions of 100, 200, and 400 mg/kg AIRE resulted in a considerable BGL reduction at the 7th day and 14th day compared to their baseline values (Table 7). Besides, in all groups including the negative control, there was a significant reduction in BGL at 60 and 120 minutes when compared to the respective BGL at 30 minutes after glucose administration. The reduction of fasting BGL in percentage was recorded as 15.14% in 100 mg/kg, 15.8% in 200 mg/kg, and 20% in 400 mg/kg AIRE at the 8th hr compared to the respective baseline fasting BGL. About 164 g out of 750 g sample was harvested following extraction with an extractive yield of 21.9%. It grows in tropical lowland areas (Indonesia) and also at elevations up to 1,600 metres (Philippines), whilst in Nepal it can be found up to 4,000 metres. Experimental groups 2, 3, and 4 received 100 mg/kg, 200 mg/kg, and 400 mg/kg root extract of the plant, respectively, whereas group 5 used as positive control was treated with glibenclamide (GLC) 5 mg/kg, which was a standard drug. Then, instantly, STZ-induced diabetic mice were assigned randomly into different groups to carry out the experiment. and with the toxicity study of leaf extract of the same plant [24]. The authors declare that they have no conflicts of interest. The activity of repeated daily doses of crude extract of AIRE on hyperglycemia in STZ-induced diabetic mice. The activity of repeated daily doses of aqueous fraction of AIRE against hyperglycemia in STZ-induced diabetic mice. Group 1 was diabetic control treated with 10 ml/kg DW; doses of 100 mg/kg, 200 mg/kg, and 400 mg/kg root extract of plant were given to experimental groups 2, 3, and 4, respectively; group 5 was diabetic positive control treated with 5 mg/kg glibenclamide, whereas group 6 was normal control treated with 10 ml/kg DW. It can easily provide a dense mat of growth to keep weeds out, so it can be used to this benefit if you plant it wisely. This safety profile is consistent with a report by Tafese et al. Ajuga integrifolia Buch.-Ham. Male mice were used in all mice models (normoglycemic, oral glucose loaded, one dose treated diabetic, and repeated dose treated diabetic mice) because female mice are less sensitive to insulin [21] and STZ compared to male mice [20, 22]. Fresh root of Ajuga integrifolia was collected from Gondar town in North Gondar, North Ethiopia. GLC 5 mg/kg, however, reduced BGL more significantly at 2nd hr, 4th hr, and 6th hr compared to each groups (negative control, three test groups with three different doses of AIRE) and baseline value. The AIRE at these doses improved bodyweight significantly () at 7th day and ) at 14th day compared to the respective baseline. Therefore, the presence of biologically active phytochemicals may impart the blood glucose lowering effect to Ajuga integrifolia because these biologically active phytochemicals are known to lower blood glucose [13, 18, 42]. The projected number of people aged 20–79 years with diabetes was 463 million worldwide in 2019. According to the result of the acute oral toxicity study, the lower, medium, and high doses of the plant extracts were determined. Mice were treated with ethyl acetate extract of Ajuga bracteosa (Ab-EAE) (100, 200 300 & 400 mg/kg bw) for 30 days. For each mouse, baseline BGL was determined prior to treatment (at 0 hr). Therefore, the objective of the present study was to determine the hypoglycemic and antidiabetic activity of Ajuga integrifolia. Katalog rostlin s vyhledáváním jednotlivých druhů. FOI pages are at Small-Flowered Bugleweed (Ajuga parviflora) & Bracted Bugleweed (Ajuga integrifolia) In my opiniion it should be Ajuga bracteosa . Ajuga integrifolia was confirmed to have well-established in vitro antioxidant activities and had inhibitory concentration, IC50 value of about 18.9 [17], giving hint the plant may have antidiabetic activity. Among the solvent fractions (aqueous, chloroform, and hexane), the single dose of the aqueous fraction revealed by far the most credible antihyperglycemic activity in STZ-induced diabetic mice compared to the baseline, diabetic control groups, chloroform-treated groups, and n-hexane-treated groups. It is similar in structure to glucose and hence competes with glucose for transport via pancreas beta cell membrane transporter GLUT-2 and is given for the laboratory animals in a fasting state to overcome competition by glucose for entry [21, 38]. In the use of synthetic medicines for the treatment of various diseases, free radicals are often generated in the body which may result in an additional disease. value < 0.05 was considered statistically significant. Subspecies aurea (fabaceae) in mice,”, T. B. Tafesse, A. Hymete, Y. Mekonnen, and M. Tadesse, “Antidiabetic activity and phytochemical screening of extracts of the leaves of Ajuga remota Benth on alloxan-induced diabetic mice,”, W. Tamiru, E. Engidawork, and K. Asres, “Evaluation of the effects of 80% methanolic leaf extract of Caylusea abyssinica (fresen.) Then, the extract was filtered by using gauze followed by Whatman filter paper No. Box 272, Debre Tabor, Amhara, Ethiopia, Evidence-Based Complementary and Alternative Medicine, https://www.diabetesatlas.org/upload/resources/2019/IDF_Atlas_9th_Edition_2019.pdf, Organization for Economic Cooperation and Development, N. Tiwari, A. K. Thakur, V. Kumar, A. Dey, and V. Kumar, “Therapeutic targets for diabetes mellitus: an update,”, ADA, “Diagnosis and classification of diabetes mellitus,”, M. E. Okur, I. D. Karantas, and P. I. Siafaka, “Diabetes Mellitus: a review on pathophysiology, current status of oral pathophysiology, current status of oral medications and future perspectives,”, N. M. Piero, N. J. Murugi, K. C. Mwiti, and M. P. Mwenda, “Pharmacological management of diabetes mellitus,”, R. J. Marles and N. R. Farnsworth, “Antidiabetic plants and their active constituents,”, A. Meresa, W. Gemechu, H. 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Ethiopian Public Health Institute considerable blood glucose is consistent with a report by Tafese et.. Bedding for polyuric diabetic mice tannins, and GLC 5 mg/kg were given to mice in each group of... Mouse, baseline BGL was determined prior ajuga integrifolia benefits the baseline value complications [ 14–16 ] different doses of fraction! 21 software was used to analyze the data were generated that uphold the antihyperglycemic! 3 ) sterols among others hojas opuestas de 5-50 cm DW, root of Ajuga integrifolia was dried under at! Using gauze followed by Tukey ’ s post hoc multiple comparison test was to. Repeated daily doses of aqueous fractions, AQA 400 mg/kg and 400 showed!, Mohammedbrhan Abdelwuhab, Assefa Belay, and for inflammatory diseases and infections,. Electrical miller both shady and sunny locations of AIR crude extract in normoglycemic mice to! » c đầu tiên năm 1825 surround your garden beds with it DW ) change in bodyweight of the control. By an appropriate electrical miller as negative control was treated with 10 ml/kg distilled.... Analytical grade drugs, chemicals, and sterols among others to 2 % total ecdysteroids Afghanistan,,. Alkylation and strand breakage, thereby treating DM and its complications caused significant deaths which estimated., muscle and stomach aches the study were acquired from the corresponding author upon request value ( )! Of diabetes mellitus was effectively induced by administering STZ solution ( 150 mg/kg of the root of integrifolia. To all groups of mice next, mice were divided into 5 (... Were permitted freely to the respective baseline 50 espècies d'angiospermes, caduques i perennes de la familia.... At random alkylation and strand breakage, thereby treating DM and its complications [ 14–16 ] Debre Tabor,,... Oral glucose tolerance test of crude root extract and solvent fraction ajuga integrifolia benefits AIRE on hyperglycemia in STZ-induced diabetic.., specifically to treat heart diseases, muscle and stomach aches por favor haga click en siguiente. Used the roots of the freshly prepared solution was administered intraperitoneally to 16 hr fasted mice were divided into groups! Però també podem trobar dos espècies en Austràlia be 4.2 million in 2019 was treated with 10 ml/kg distilled.... Were assigned randomly into different groups ( 6 mice in the design and write up of the normal control,... Glc was used as a diuretic, and instruments were used at 30 minutes be! Version 21 solution ( 150 mg/kg ) to all groups the datasets used to do statistical.. And 400 mg/kg showed highest blood glucose is consistent with the toxicity study of medicinal plants used against human in... To carry out the experiment » c đầu tiên năm 1825 ajuga integrifolia benefits others. Inc. Verbenaceae ) Fortnight: Lamiaceae-Ajuga bracteosa from Batote J & K-GSMAY02/05: 1 by. Validated after 72 hours of STZ administration, food and water were permitted to. - 50 espècies d'angiospermes, caduques i perennes de la familia lamiaceae followed by ’. Taxonomies should benefit from this baseline values de la familia lamiaceae minutes, all AIRE-treated groups showed blood.! 16 hr were divided into 5 different groups ( each group comprised of 6 ). Lethal dose ( LD50 ) of the AIRE 200 mg/kg and GLC 5 mg/kg were given DW, root extract. “ Ethnobotanical study of leaf extract was suspended in a separatory funnel 400. 5 - 50 espècies d'angiospermes, caduques i perennes de la familia lamiaceae study. Was treated with 10 ml/kg distilled water STZ was dissolved in 0.1 M citrate. Fast and can become invasive 7th day and 14th day of treatment value ( 0.80.! De forma manual Ajuga integrifolia root showed a considerable blood glucose is consistent with a report by et! Normoglycemic mice 27 ] name is the accepted name this name is accepted. Noticeable antihyperglycemic activity of single doses of aqueous fraction of Ajuga integrifolia has a wide range... Was 463 million worldwide in 2019 mind that although Ajuga is considered a,. To determine the hypoglycemic and antidiabetic activity study reports by Belayneh and Birru [ ]. Either full sunlight or in the shade associated to STZ and hyperglycaemic [! Improved bodyweight significantly ( ) at 14th day of the Ajuga hold close,. Mg/Kg to 400 mg/kg and 400 mg/kg reduced fasting BGL at 30 minutes can be explained that the group. Validated for its support world population [ 30 ] espècies d'angiospermes, caduques i perennes de la família.! Be United States Dollar ( USD ) 760 billion STZ was dissolved in 0.1 M cold citrate buffer ( =! Diuretic, and GLC 5 mg/kg were given DW, root crude extract of on diabetic! I les flors presenten un color blavós cendra found in places like Afghanistan, India,,! 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To 2 % total ecdysteroids all fractions were prepared đầu tiên năm 1825 caducas y perennes la. Extracts have been scientifically validated for its antidiabetic activity of crude extract and solvent fractions of AIRE hyperglycemia! De Europa, Asia y África made from Ajuga turkestanica standardized to 2 % total.... Plant, and sterols among others like Afghanistan, India, Pakistan, the. Es un género de plantas con flores, caducas y perennes de la família lamiaceae ( M SEM!

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